Restriction Summary

Find and report all restriction enzyme cut sites in DNA sequences.

Tool Configuration
Configure the parameters for Restriction Summary

Paste one or more FASTA sequences (max 100,000,000 characters).

Treat sequences as linear or circular molecules.

1

Input DNA Sequences

Paste one or more DNA sequences in FASTA format. The tool supports sequences up to 100 million characters and automatically removes non-DNA characters. Ideal for plasmids, genes, or genomic regions.

2

Select Molecule Topology

Choose "Linear" for PCR products, genes, or linear plasmids. Choose "Circular" for plasmids and vectors to detect restriction sites that span the origin. Circular mode checks for sites across the sequence junction.

3

Review Restriction Map

The output lists all restriction enzymes that cut your sequence, showing the enzyme name, recognition pattern, and exact positions (1-indexed) of each cut site. Enzymes are grouped by number of cuts for easy identification of unique cutters.

4

Practical Applications

Use this tool for quick plasmid verification, finding unique restriction sites for cloning, checking for unwanted restriction sites in inserts, or planning restriction mapping experiments. Single-cutters are particularly useful for linearizing plasmids.

Restriction Site Mapping
Locating restriction enzyme cut sites in DNA sequences.

What is a Restriction Summary?

This tool scans DNA sequences for recognition sites of common restriction enzymes and reports their locations. Unlike restriction digest which physically cuts the DNA, restriction summary just identifies where enzymes would cut.

How It Works

The tool:
  • • Searches for all standard restriction enzyme sites
  • • Reports positions of each enzyme site (1-indexed)
  • • Counts total occurrences per enzyme
  • • Handles both linear and circular DNA
  • • Produces a comprehensive restriction map

Use Cases

Quick restriction mapping for plasmid verification, checking for enzyme sites in sequences, and planning cloning strategies.